Dengue and Zika – A Global Health Threat

UMTMOOC ADMIN
Photography
  • 15 students
  • 18-12-2018
  • Flexible
15 students

This course introduces Dengue and Zika diseases which are caused by two viruses of the same family; Dengue virus and Zika virus. This course explains the biology of each viruses in terms of their structure, genome organization and replication strategy in cellular hosts. Transmission of both Dengue and Zika viruses…

This course introduces Dengue and Zika diseases which are caused by two viruses of the same family; Dengue virus and Zika virus. This course explains the biology of each viruses in terms of their structure, genome organization and replication strategy in cellular hosts. Transmission of both Dengue and Zika viruses to susceptible individuals occurs through mosquitoes as an arthropod vector. Thus, factors correlating the mosquito biology, ecology and human behaviour may contribute to the dynamics of dengue, which will be explained further in this course. The impact of both Dengue and Zika viral infections to human immune system resulting asymptomatic or severe clinical manifestations will also be discussed. Further, this course highlights current lab diagnosis and treatment, as well as the progress of development of antiviral therapy and vaccine against both viruses.

 

 




This course introduces Dengue and Zika diseases which are caused by two viruses of the same family; Dengue virus and Zika virus. This course explains the biology of each viruses in terms of their structure, genome organization and replication strategy in cellular hosts. Transmission of both Dengue and Zika viruses to susceptible individuals occurs through mosquitoes as an arthropod vector. Thus, factors correlating the mosquito biology, ecology and human behaviour may contribute to the dynamics of dengue, which will be explained further in this course. The impact of both Dengue and Zika viral infections to human immune system resulting asymptomatic or severe clinical manifestations will also be discussed. Further, this course highlights current lab diagnosis and treatment, as well as the progress of development of antiviral therapy and vaccine against both viruses.




Specifically, the objectives of this course are the followings:-

  • Basic biology of Dengue and Zika viruses
  • Threat from Dengue and Zika to the community
  • Morphological characteristics of vectors
  • Host Preferences by the vectors
  • Blood Feeding and Egg development process in vectors
  • Biting and resting habits
  • Breeding sites characteristics
  • Life cycle
  • Environmental thresholds that limits vector distribution  and expansion
  • Aedes mosquito attractants
  • Vector monitoring and surveillance
  • Control methods
  • Dissemination of Viruses in Mosquito
  • Establishment of Mosquito Cell Lines
  • Mosquito Innate Immunity
  • How the pathways mechanism antibody dependent enhancement
  • Current labaratory diagnostic method in Dengue and Zika infection
  • Advantages and limitation to current diagnostic methods
  • Clinical management for Dengue and Zika infection
  • Myth about Dengue and Zika
  • Development and challenges of antiviral against Dengue and Zika
  • Development and challenges of vaccine against Dengue and Zika
  • Anti- Dengue research UMT




By the end of the course student should be able to learn and describe:- 

  1. The basic biology of Dengue and Zika viruses
  2. The world distribution of both diseases
  3. How Dengue and Zika are transmitted to humans
  4. Why both Dengue and Zika pose a significant threat to the community;
  5. Identified the vectors for Dengue and Zika
  6. Describe the life cycle and breeding requirements of the vectors
  7. Describe the behaviour of the vectors which is related to their efficiency in transmission of Dengue and Zika viruses;
  8. Explain how mosquito population monitoring and surveillance is done
  9. Describe the common and current methods used to control dengue and zika vector
  10. Suggest integrated approach in controlling Dengue and Zika vectors;
  11. The process of how virus infects and disseminates in its mosquito host
  12. The establishment of mosquito cell lines as a tool for virus research
  13. The interplay of mosquito antiviral defense mechanism during viral infection;
  14. What cells involved to halt virus infections
  15. How an antibody response to Dengue and Zika viruses
  16. Dengue virus infection falls into primary, secondary and tertiary infection
  17. Both Dengue and Zika are transmitted via the bite of an infected Aedes species mosquito;

*Join the course for further details on learning outcomes

Status Duration: Self-paced 

SME/Lecturer:

Dr. Suzana Misbah- Course Coodinator
Dr. Nur Aida Hashim
Dr. Nor Omaima Harun
Dr. Siti Nur Khadijah Addis




Topic 1 - Introduction to Dengue and Zika

Topic 2 - Biology , Ecology and behaviour of Dengue & Zika Vectors (Aedes sp.)

Topic 3 - Vector control strategies

  • What are our strategies to prevent Dengue and Zika
  • Vector control strategies

Topic 4 - How do they subvert mosquito immune response?

Topic 5 - How does our body control virus infection?

  • Human Immune Pathways - Theory about antibody dependent enhancement

Topic 6 - How does our body control virus infection?

  • Human immune system

Topic 7 - Labaratory diagnosis for Dengue & Zika infection

  • What are ways to detect and manage dengue?

Topic 8 - Current treatment and myth about Dengue and Zika infection

  • What are current treatment for Dengue and Zika?

Topic 9 - Development of antiviral and vaccine against Dengue and Zika viruses


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